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Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2012 (English)In: New Perspectives of Central Nervous System Injury and Neuroprotection / [ed] Sharma, HS, Elsevier, 2012, 107-146 p.Chapter in book (Refereed)
Abstract [en]

Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging-related brain disorders. This review is focused on the new developments in oxidative stress-induced neurodegeneration. Further, based on our own investigations, new roles of quercetin, an antioxidant compound in hypoxia and ischemia induced neuroprotection in relation to suppression of oxidative stress, improvement in behavioral function, reduction in infarct volume, brain swelling, and cellular injury in both in vivo and in vitro models are discussed. Our new findings clearly suggest that antioxidant compounds have potential role in therapeutic strategies to treat neurodegenerative diseases in clinical settings.

Place, publisher, year, edition, pages
Elsevier, 2012. 107-146 p.
Series
International Review of Neurobiology, ISSN 0074-7742 ; 102
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-181631DOI: 10.1016/B978-0-12-386986-9.00005-3ISI: 000308201000006PubMedID: 22748828ISBN: 978-0-12-386986-9 (print)OAI: oai:DiVA.org:uu-181631DiVA: diva2:557175
Available from: 2012-09-27 Created: 2012-09-27 Last updated: 2015-05-26Bibliographically approved

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Sharma, ArunaSharma, Hari Shanker

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