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Measurements of Brownian relaxation of magnetic nanobeads using planar Hall effect bridge sensors
Dept of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Kongens Lyngby, Danmark.
Dept of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Kongens Lyngby, Danmark.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material, Nanotechnology and Functional Materials)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material, Nanotechnology and Functional Materials)
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2012 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 40, no S1, 147-152 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

We compare measurements of the Brownian relaxation response of magnetic nanobeads in suspension using planar Hall effect sensors of cross geometry and a newly proposed bridge geometry. We find that the bridge sensor yields six times as large signals as the cross sensor, which results in a more accurate determination of the hydrodynamic size of the magnetic nanobeads. Finally, the bridge sensor has successfully been used to measure the change in dynamic magnetic response when rolling circle amplified DNA molecules are bound to the magnetic nanobeads. The change is validated by measurements performed in a commercial AC susceptometer. The presented bridge sensor is, thus, a promising component in future lab-on-a-chip biosensors for detection of clinically relevant analytes, including bacterial genomic DNA and proteins.

Place, publisher, year, edition, pages
2012. Vol. 40, no S1, 147-152 p.
National Category
Nano Technology Engineering and Technology
Research subject
Engineering Science with specialization in Solid State Physics; Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-181808DOI: 10.1016/j.bios.2012.07.002ISI: 000312825800024PubMedID: 22841901OAI: oai:DiVA.org:uu-181808DiVA: diva2:557876
Conference
22nd Anniversary World Congress on Biosensors / Summer School on Printed Biosensors and Electronics, 15-18 May, 2012, Cancun, MEXICO
Available from: 2012-10-01 Created: 2012-10-01 Last updated: 2017-12-07Bibliographically approved

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Zardán Gómez de la Torre, TeresaStrömberg, MattiasStrømme, MariaSvedlindh, Peter

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Nanotechnology and Functional MaterialsSolid State Physics
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