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Monitoring the Distribution of Warfarin in Blood Plasma
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Physical Organic Chemistry.
2012 (English)In: ACS Medicinal Chemistry Letters, ISSN 1948-5875, E-ISSN 1948-5875, Vol. 3, no 8, 650-652 p.Article in journal (Refereed) Published
Abstract [en]

Warfarin is an anticoagulant drug extensively used in the treatment and prevention of thrombotic disorders. Previous studies have shown that warfarin binds extensively to blood plasma proteins and that only a small fraction of the drug is unbound and thus available for therapeutic function. Both warfarin's narrow therapeutic window and the susceptibility of anticoagulant function to patient-dependent factors necessitate regular monitoring. In this study, we have shown that the lifetimes for each of the various bound and free forms of the drug in blood plasma can be quantified in situ by time-correlated single-photon counting fluorescence spectroscopy over the clinically significant concentration range. A relationship between the blood coagulation and the distribution of fluorescence lifetimes was observed. The in situ detection of clinically relevant concentrations of warfarin in its respective bound and unbound forms could provide a prognostic tool for use in patient treatment.

Place, publisher, year, edition, pages
2012. Vol. 3, no 8, 650-652 p.
Keyword [en]
warfarin, coagulation, plasma, TCSPC, fluorescence spectroscopy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-181865DOI: 10.1021/ml300112eISI: 000307478600013OAI: oai:DiVA.org:uu-181865DiVA: diva2:558007
Available from: 2012-10-01 Created: 2012-10-01 Last updated: 2017-12-07Bibliographically approved

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Nicholls, Ian A.

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