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Environmental exposure to arsenic and cadmium during pregnancy and fetal size: a longitudinal study in rural Bangladesh
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Japan.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research, Mahakhali, Dhaka, Bangladesh.
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2012 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 34, no 4, 504-511 p.Article in journal (Refereed) Published
Abstract [en]

Prenatal exposures to arsenic (As) and cadmium (Cd) have been associated with decreased size at birth. We here studied associations of prenatal As and Cd exposures with multiple fetal size parameters measured by ultrasound in gestational week (GW) 14 and 30 in a population-based mother-child cohort in rural Bangladesh. We measured As (n=1929) and Cd (n=1616) in urine during pregnancy. In the longitudinal evaluation of combined exposure, urinary Cd (UCd) showed an inverted U-shaped association (turning-point 1.5μg Cd/L) with all fetal size parameters, while UAs showed no significant association. Cross-sectional analyses indicated that associations with UCd were somewhat stronger in early gestation. Stratification indicated stronger associations between UCd and fetal size in girls than in boys, and in poorer than in richer families, while UAs was weakly associated with fetal size in boys. In conclusion, particularly Cd, but also As, appeared to influence fetal development in a sex-dependent manner.

Place, publisher, year, edition, pages
2012. Vol. 34, no 4, 504-511 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-181902DOI: 10.1016/j.reprotox.2012.08.002ISI: 000312427600003PubMedID: 22985739OAI: oai:DiVA.org:uu-181902DiVA: diva2:558035
Available from: 2012-10-01 Created: 2012-10-01 Last updated: 2013-01-22Bibliographically approved

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Persson, Lars-Åke
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