The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
2013 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 333, no 2, 222-228 p.Article in journal (Refereed) Published
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma–infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response.
Place, publisher, year, edition, pages
2013. Vol. 333, no 2, 222-228 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-181908DOI: 10.1016/j.canlet.2013.01.036ISI: 000318838700011OAI: oai:DiVA.org:uu-181908DiVA: diva2:558058