uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Somatostatin receptor expression in non-medullary thyroid carcinomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
Show others and affiliations
2012 (English)In: Hormones, ISSN 1109-3099, Vol. 11, no 3, 290-296 p.Article in journal (Refereed) Published
Abstract [en]


Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid cancers in order to be able to recommend the use of PRRT as a treatment option in patients with progressive local or metastatic disease.


We constructed tissue microarrays from paraffin blocks prepared from 47 cases of non-medullary thyroid carcinomas and related normal thyroid tissue. Immunohistochemical staining was performed with five different polyclonal SSTR antibodies.


SSTR subtypes sst2 and sst3 were expressed in all non-medullary thyroid carcinomas, sst1 and sst5 in 75%, and sst4 in 38%. Coexpression of more than three subtypes was detected in 36 of the 47 cases. The expression of SSTR subtypes in normal thyroid tissue was low or absent.


Non-medullary thyroid carcinomas frequently express all SSTR subtypes. This expression provides a basis for further studies with the aim of exploring PRRT as a possible new treatment for iodine-131 refractory metastatic non-medullary thyroid carcinomas.

Place, publisher, year, edition, pages
2012. Vol. 11, no 3, 290-296 p.
Keyword [en]
Thyroid carcinoma, Somatostatin receptor, Tissue microarray, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-182035ISI: 000308215300006OAI: oai:DiVA.org:uu-182035DiVA: diva2:558915
Available from: 2012-10-05 Created: 2012-10-02 Last updated: 2015-02-27

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Tiensuu Janson, EvaStridsberg, Mats
By organisation
Endocrine OncologyBiochemical endocrinology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 195 hits
ReferencesLink to record
Permanent link

Direct link