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High levels of cathepsins B, L and S in human seminal plasma and their association with prostasomes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. (Klinisk kemi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. (Klinisk kemi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. (Klinisk kemi)
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2012 (English)In: Andrologia, ISSN 0303-4569, E-ISSN 1439-0272, Vol. 44, no 6, 423-427 p.Article in journal (Refereed) Published
Abstract [en]

Semen is a heterogenous and complex fluid with different functions, some of them well known, others still obscure. The aim of this study was to investigate the presence of cathepsins B, S and L in human seminal plasma and their possible associations with other semen variables. Cathepsin B, L and S concentrations were measured in seminal plasma from 99 men utilising commercial ELISA kits. Seminal plasma cathepsin B was approximately 70 times higher, while the cathepsin L values were approximately 500 times higher and the cathepsin S values approximately 40 times higher in seminal plasma than in a group of serum samples. The study shows that seminal plasma contains high levels of cathepsins B, L and S. All three cathepsins were also bound to the surface of prostasomes.

Place, publisher, year, edition, pages
2012. Vol. 44, no 6, 423-427 p.
National Category
Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-182323DOI: 10.1111/j.1439-0272.2012.01299.xISI: 000310476700011PubMedID: 22571763OAI: oai:DiVA.org:uu-182323DiVA: diva2:559455
Available from: 2012-10-09 Created: 2012-10-09 Last updated: 2017-12-07Bibliographically approved

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Larsson, AndersRonquist, GöranCarlsson, Lena

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