Cerebrospinal fluid cathepsin B and S
2013 (English)In: Neurological Sciences, ISSN 1590-1874, E-ISSN 1590-3478, Vol. 34, no 4, 445-448 p.Article in journal (Refereed) Published
Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF.
Place, publisher, year, edition, pages
2013. Vol. 34, no 4, 445-448 p.
IdentifiersURN: urn:nbn:se:uu:diva-182337DOI: 10.1007/s10072-012-1022-0ISI: 000317348400005PubMedID: 22441732OAI: oai:DiVA.org:uu-182337DiVA: diva2:559468