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Cerebrospinal fluid cathepsin B and S
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. (Klinisk kemi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. (Klinisk kemi)
2013 (English)In: Neurological Sciences, ISSN 1590-1874, E-ISSN 1590-3478, Vol. 34, no 4, 445-448 p.Article in journal (Refereed) Published
Abstract [en]

Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF.

Place, publisher, year, edition, pages
2013. Vol. 34, no 4, 445-448 p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-182337DOI: 10.1007/s10072-012-1022-0ISI: 000317348400005PubMedID: 22441732OAI: oai:DiVA.org:uu-182337DiVA: diva2:559468
Available from: 2012-10-09 Created: 2012-10-09 Last updated: 2017-12-07Bibliographically approved

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Nilsson, ElinGordh, TorstenLarsson, Anders

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