A non-resonant microwave applicator fully dedicated to continuous flow chemistry
2012 (English)In: Chimica oggi, ISSN 0392-839X, Vol. 30, no 4, 14-16 p.Article in journal (Refereed) Published
The concept of a non-resonant microwave applicator designed for continuous flow chemistry was introduced by our group this year. With a power output of 0 - 150 W, adjustable frequency range of 2.4 - 2.5 GHz and five IR sensors monitoring the temperature along a tubular borosilicate reactor, the instrument ensures fast, efficient and uniform heating. A variety of organic reactions were optimized for continuous flow chemistry using a 200 mm x empty set 3 mm reactor, which proved the instrument to be an unprecedented tool for fast method optimization. A scale-out study is now reported where reactions already optimized in a empty set 3 mm reactor are run in a empty set 6 mm reactor, aiming for a fourfold increase in chemical throughput with no or little need for re-optimization.
Place, publisher, year, edition, pages
2012. Vol. 30, no 4, 14-16 p.
Microwave, continuous flow, non-resonant, scale-out, scale-up, microwave-assisted organic synthesis, tubular reactor
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-182258ISI: 000307789300003OAI: oai:DiVA.org:uu-182258DiVA: diva2:559644