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A non-resonant microwave applicator fully dedicated to continuous flow chemistry
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2012 (English)In: Chimica oggi, ISSN 0392-839X, E-ISSN 1973-8250, Vol. 30, no 4, 14-16 p.Article in journal (Refereed) Published
Abstract [en]

The concept of a non-resonant microwave applicator designed for continuous flow chemistry was introduced by our group this year. With a power output of 0 - 150 W, adjustable frequency range of 2.4 - 2.5 GHz and five IR sensors monitoring the temperature along a tubular borosilicate reactor, the instrument ensures fast, efficient and uniform heating. A variety of organic reactions were optimized for continuous flow chemistry using a 200 mm x empty set 3 mm reactor, which proved the instrument to be an unprecedented tool for fast method optimization. A scale-out study is now reported where reactions already optimized in a empty set 3 mm reactor are run in a empty set 6 mm reactor, aiming for a fourfold increase in chemical throughput with no or little need for re-optimization.

Place, publisher, year, edition, pages
2012. Vol. 30, no 4, 14-16 p.
Keyword [en]
Microwave, continuous flow, non-resonant, scale-out, scale-up, microwave-assisted organic synthesis, tubular reactor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-182258ISI: 000307789300003OAI: oai:DiVA.org:uu-182258DiVA: diva2:559644
Available from: 2012-10-10 Created: 2012-10-08 Last updated: 2017-12-07Bibliographically approved

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Fardost, AshkanLarhed, Mats

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