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Circular Proteins from Plants and Fungi
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Ulf Göransson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Ulf Göransson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Ulf Goöansson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. (Ulf Göransson)ORCID iD: 0000-0001-9070-6944
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2012 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 287, no 32, 27001-27006 p.Article, review/survey (Refereed) Published
Abstract [en]

Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthesis, represent a novel class of natural products attracting increasing interest. From a scientific point of view, these compounds raise questions of where and why they occur in nature and how they are formed. From a rational point of view, these proteins and their structural concept may be exploited for crop protection and novel pharmaceuticals. Here, we review the current knowledge of three protein families: cyclotides and circular sunflower trypsin inhibitors from the kingdom of plants and the Amanita toxins from fungi. A particular emphasis is placed on their biological origin, structure, and activity. In addition, the opportunity for discovery of novel circular proteins and recent insights into their mechanism of action are discussed.

Place, publisher, year, edition, pages
2012. Vol. 287, no 32, 27001-27006 p.
National Category
Medicinal Chemistry
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URN: urn:nbn:se:uu:diva-182331DOI: 10.1074/jbc.R111.300129ISI: 000307386000048OAI: oai:DiVA.org:uu-182331DiVA: diva2:559769
Available from: 2012-10-10 Created: 2012-10-09 Last updated: 2017-12-07Bibliographically approved

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Göransson, UlfBurman, RobertGunasekera, SunithiStrömstedt, Adam A.

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