uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Development of multifunctional hyaluronic acid-based carriers by 'click' chemistry
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Show others and affiliations
2012 (English)In: Journal of Tissue Engineering and Regenerative Medicine, ISSN 1932-6254, Vol. 6, no suppl 1, 191-192 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Introduction: We have developed methods to simultaneously introduce chemoselective groups to hyaluronic acid (HA) that can be crosslinked and used for immobilization of various molecules. It is easy to switch the functionalities of obtained materials through orthogonal ‘click’ chemistries.

Methods: HA polymers were dually functionalized with hydrazide and thiol groups, or aldehyde groups. Different functional molecules such as bisphosphonate (BP) groups for mineralization or camptothecin (CPT) as anti-cancer drug can be linked to thiol groups. HA polymers were characterized by 1H, 31P NMR, and UV-Vis Spectroscopy. Characterizations of materials were performed using SEM, TEM, rheology, and colorimetric calcium assay.

Results and discussion: The functional polymers were successfully synthesized. They can form hydrogels within 1 min with HA-aldehyde polymer. BP groups showed high affinity to calcium ions and inorganic nanoparticle phases were observed within BP containing hybrid hydrogel. On the other hand, CPT-linked HA polymer via S-S bond can self-assembled into nanoparticles, and the release of the drug is triggered by the addition of reduce agents (e.g. dithiothreitol).

Conclusions: The use of orthogonal click modification opened a versatile way to prepare different kinds of HA based carriers with various functionalities by simple methods. The multifunctional HA polymers show high potentials to be used for drug delivery (pro-drug) or tissue regeneration (BP linked HA).

Place, publisher, year, edition, pages
2012. Vol. 6, no suppl 1, 191-192 p.
National Category
Medical and Health Sciences Engineering and Technology Polymer Chemistry
Research subject
Engineering Science with specialization in Materials Science; Chemistry with specialization in Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-182411DOI: 10.1002/term.1586ISI: 000308313001308OAI: oai:DiVA.org:uu-182411DiVA: diva2:560263
Available from: 2012-10-12 Created: 2012-10-10 Last updated: 2013-01-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Yang, XiaAkhtar, SultanLeifer, KlausHilborn, JönsOssipov, Dmitri

Search in DiVA

By author/editor
Yang, XiaAkhtar, SultanLeifer, KlausHilborn, JönsOssipov, Dmitri
By organisation
Polymer ChemistryApplied Materials Sciences
Medical and Health SciencesEngineering and TechnologyPolymer Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 1353 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf