Highly Enantioselective Iridium-Catalyzed Hydrogenation of α,β-Unsaturated Esters
2012 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 18, no 34, 10609-10616 p.Article in journal (Refereed) Published
α,β-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.
Place, publisher, year, edition, pages
2012. Vol. 18, no 34, 10609-10616 p.
IdentifiersURN: urn:nbn:se:uu:diva-182641DOI: 10.1002/chem.201200907ISI: 000307387300020PubMedID: 22807347OAI: oai:DiVA.org:uu-182641DiVA: diva2:560430