uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus.
John Curtin School of Medical Research, Australian National University.
2000 (English)In: Journal of Membrane Biology, ISSN 0022-2631, E-ISSN 1432-1424, Vol. 174, no 1, 21-9 p.Article in journal (Refereed) Published
Abstract [en]

Spontaneous, single channel, chloride currents were recorded in 48% of cell-attached patches on neurones in the CA1 region of rat hippocampal slices. In some patches, there was more than 1 channel active. They showed outward rectification: both channel conductance and open probability were greater at depolarized than at hyperpolarized potentials. Channels activated by gamma-aminobutyric acid (GABA) in silent patches on the same neurones had similar conductance and outward rectification. The spontaneous currents were inhibited by bicuculline and potentiated by diazepam. It was concluded that the spontaneously opening channels were constitutively active, nonsynaptic GABA(A) channels. Such spontaneously opening GABA(A) channels may provide a tonic inhibitory mechanism in these cells and perhaps in other cells that have GABA(A) receptors although not having a GABA(A) synaptic input. They may also be a target for clinically useful drugs such as the benzodiazepines.

Place, publisher, year, edition, pages
2000. Vol. 174, no 1, 21-9 p.
National Category
Neurosciences Physiology
URN: urn:nbn:se:uu:diva-182736PubMedID: 10741429OAI: oai:DiVA.org:uu-182736DiVA: diva2:560710
Available from: 2012-10-15 Created: 2012-10-15 Last updated: 2012-10-15

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Birnir, Bryndis
In the same journal
Journal of Membrane Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 277 hits
ReferencesLink to record
Permanent link

Direct link