uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nature of the 5' residue in the M2 domain affects function of the human alpha 1 beta 1 GABAA receptor.
John Curtin School of Medical Research, Australian National University.
Show others and affiliations
1997 (English)In: Synapse, ISSN 0887-4476, E-ISSN 1098-2396, Vol. 26, no 3, 324-7 p.Article in journal (Refereed) Published
Abstract [en]

The effects on the functional properties of the alpha 1 beta 1 GABAA receptor when the 5' (alpha 1 Val260; beta 1 Ile255) hydrophobic amino acids in the second transmembrane (M2) region were changed to threonine were examined. In response to a saturating concentration of GABA, the current evoked in mutant receptors showed a decreased rate of desensitization and at equilibrium was a greater fraction of the peak current than in wild-type receptors. The half-saturation concentration of the peak current response to GABA in mutant receptors was comparable to that in wild-type receptors, but the Hill coefficient was reduced to less than one. It was concluded that the 5' amino acids in the M2 region have a role in the conformational changes that occur within the alpha 1 beta 1 GABAA receptor in response to GABA.

Place, publisher, year, edition, pages
1997. Vol. 26, no 3, 324-7 p.
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-182792DOI: 10.1002/(SICI)1098-2396(199707)26:3<324::AID-SYN13>3.0.CO;2-VPubMedID: 9183821OAI: oai:DiVA.org:uu-182792DiVA: diva2:560718
Available from: 2012-10-15 Created: 2012-10-15 Last updated: 2017-12-07

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Birnir, Bryndis

Search in DiVA

By author/editor
Birnir, Bryndis
In the same journal
Synapse
Physiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 678 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf