Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
2012 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 44, no 9, 981-+ p.Article in journal (Refereed) Published
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
Place, publisher, year, edition, pages
2012. Vol. 44, no 9, 981-+ p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-182771DOI: 10.1038/ng.2383ISI: 000308491200009OAI: oai:DiVA.org:uu-182771DiVA: diva2:561171