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Good penetration of moxifloxacin into human abscesses
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Farmakometri)ORCID iD: 0000-0003-3531-9452
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2012 (English)In: Pharmacology, ISSN 0031-7012, E-ISSN 1423-0313, Vol. 90, no 3-4, 146-150 p.Article in journal (Refereed) Published
Abstract [en]

Abscesses are often treated with antibiotics in addition to incision or when incision is unfeasible, but accurate information about antibiotic abscess penetration in humans is missing. This study aimed at evaluating the penetration of moxifloxacin into human abscesses. After administration of a single dose of 400 mg moxifloxacin, drug concentrations were measured in 10 differently located abscesses at incision, and in plasma over 8 h. At incision performed 0.9-4.8 h after administration, moxifloxacin concentrations in abscesses ranged from ≤0.01 to 9.2 mg/l (1.9 ± 3.4 mg/l), indicating pronounced drug accumulation in some abscesses. The degree of abscess penetration could not be explained by covariates like the ratio of surface area to volume or pH of abscesses, or by moxifloxacin plasma concentrations. Concluding, moxifloxacin was detectable in most abscesses and may be a useful antibiotic for this indication. However, antibiotic abscess penetration was highly variable and unpredictable, suggesting surgical abscess incision whenever possible.

Place, publisher, year, edition, pages
2012. Vol. 90, no 3-4, 146-150 p.
National Category
Infectious Medicine
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URN: urn:nbn:se:uu:diva-183035DOI: 10.1159/000341550ISI: 000309695900004PubMedID: 22868236OAI: oai:DiVA.org:uu-183035DiVA: diva2:561728
Available from: 2012-10-21 Created: 2012-10-21 Last updated: 2017-12-07

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Kjellsson, Maria C

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