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Regression dilution bias: Tools for correction methods and sample size calculation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
2012 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 117, no 3, 279-283 p.Article in journal (Refereed) Published
Abstract [en]

Background. Random errors in measurement of a risk factor will introduce downward bias of an estimated association to a disease or a disease marker. This phenomenon is called regression dilution bias. A bias correction may be made with data from a validity study or a reliability study.

Aims and methods. In this article we give a non-technical description of designs of reliability studies with emphasis on selection of individuals for a repeated measurement, assumptions of measurement error models, and correction methods for the slope in a simple linear regression model where the dependent variable is a continuous variable. Also, we describe situations where correction for regression dilution bias is not appropriate.

Results. The methods are illustrated with the association between insulin sensitivity measured with the euglycaemic insulin clamp technique and fasting insulin, where measurement of the latter variable carries noticeable random error. We provide software tools for estimation of a corrected slope in a simple linear regression model assuming data for a continuous dependent variable and a continuous risk factor from a main study and an additional measurement of the risk factor in a reliability study. Also, we supply programs for estimation of the number of individuals needed in the reliability study and for choice of its design.

Conclusions. Our conclusion is that correction for regression dilution bias is seldom applied in epidemiological studies. This may cause important effects of risk factors with large measurement errors to be neglected.

Place, publisher, year, edition, pages
2012. Vol. 117, no 3, 279-283 p.
Keyword [en]
Correction methods, measurement errors, regression dilution bias, SAS and R programs
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-183239DOI: 10.3109/03009734.2012.668143ISI: 000307186800004OAI: oai:DiVA.org:uu-183239DiVA: diva2:562670
Available from: 2012-10-25 Created: 2012-10-23 Last updated: 2012-10-25Bibliographically approved

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Berglund, Lars
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