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Risk factors for venous thromboembolism in pre- and postmenopausal women
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2012 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 130, no 4, 596-601 p.Article in journal (Refereed) Published
Abstract [en]


Hemostasis in women is affected by changes of estrogen levels. The role of endogenous estrogens on risk of venous thromboembolism (VTE) remains unclear. The aim of this study was to investigate the importance of acquired and genetic risk factors for VTE in pre-and postmenopausal women.


In a nationwide case–control study we included as cases 1470 women, 18 to 64 years of age with a first time VTE. The 1590 controls were randomly selected and matched by age to the cases. Information on risk factors was obtained by interviews and DNA-analyses. We used unconditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs).


The ORs were generally of similar magnitude in pre- and postmenopausal women. The highest risk was for the combination of surgery and cast (adjusted OR 54.12, 95% CI 16.62-176.19) in postmenopausal women. The adjusted OR for use of menopausal hormone therapy was 3.73 (95% CI 1.86-7.50) in premenopausal and 2.22 (95% CI 1.54-3.19) in postmenopausal women. Overweight was linked to an increased risk and exercise to a decreased risk, regardless of menopausal status.


Menopausal status had only minor influence on the risk levels. Acquired transient risk factors conveyed the highest risks for VTE.

Place, publisher, year, edition, pages
2012. Vol. 130, no 4, 596-601 p.
Keyword [en]
Venous thromboembolism, Menopause, Risk factors, Estrogens, Epidemiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-183215DOI: 10.1016/j.thromres.2012.05.024ISI: 000308919500014OAI: oai:DiVA.org:uu-183215DiVA: diva2:562783
Available from: 2012-10-26 Created: 2012-10-23 Last updated: 2012-10-26Bibliographically approved

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