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The effect of premenstrual dysphoric disorder and menstrual cycle phase on brain activity during response inhibition
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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2012 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 142, no 1-3, 347-350 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Premenstrual dysphoric disorder (PMDD) has generally not been associated with impulsive behavior. However, some studies suggest that women with PMDD have higher impulsivity scores than healthy controls and that brain activity during response inhibition may vary across the menstrual cycle. Therefore, our aim was to unravel potentially important cognitive aspects of PMDD by investigating brain activity during response inhibition in women with PMDD and healthy controls in relation to menstrual cycle phase.

METHODS:

Fourteen PMDD patients and 13 healthy controls performed a Go/NoGo task to measure brain activity during response inhibition by use of event-related functional magnetic resonance imaging.

RESULTS:

Women with PMDD displayed decreased activity during both menstrual cycle phases compared to healthy controls in several task-related parietal areas. A significant group by phase interactions was found in the left insula, driven by enhanced activity among healthy controls in the follicular phase and by enhanced insula activity during the luteal phase among PMDD patients.

LIMITATIONS:

The limitations of the present study are the relatively limited sample size, the relatively small number of NoGo trials and the lack of a baseline contrast for the NoGo trials.

CONCLUSIONS:

During response inhibition women with PMDD have reduced activity in areas associated with attention and motor function which is unrelated to menstrual cycle phase. Insular cortex activity, involved in both affective and cognitive processing, was significantly activated during the luteal phase among PMDD women. These findings are relevant for the understanding of how ovarian steroids influence mood symptoms in women.

Place, publisher, year, edition, pages
2012. Vol. 142, no 1-3, 347-350 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-183655DOI: 10.1016/j.jad.2012.04.006ISI: 000310565900051PubMedID: 22840469OAI: oai:DiVA.org:uu-183655DiVA: diva2:563660
Available from: 2012-10-31 Created: 2012-10-31 Last updated: 2017-12-07Bibliographically approved

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Bannbers, ElinGingnell, MalinEngman, JonasMorell, ArvidComasco, ErikaKask, KristiinaWikström, JohanSundström Poromaa, Inger

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Bannbers, ElinGingnell, MalinEngman, JonasMorell, ArvidComasco, ErikaKask, KristiinaWikström, JohanSundström Poromaa, Inger
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Obstetrics and GynaecologyDepartment of PsychologyRadiologyDepartment of NeuroscienceDepartment of Women's and Children's Health
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