CD11c(+) Cells Are Required for Antigen-Induced Increase of Mast Cells in the Lung
2012 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 189, no 8, 3869-3877 p.Article in journal (Refereed) Published
Patients with allergic asthma have more lung mast cells, which likely worsens the symptoms. In experimental asthma, CD11c(+) cells have to be present during the challenge phase for several features of allergic inflammation to occur. Whether CD11c(+) cells play a role for Ag-induced increases of lung mast cells is unknown. In this study, we used diphtheria toxin treatment of sensitized CD11c-diphtheria toxin receptor transgenic mice to deplete CD11c(+) cells. We demonstrate that recruitment of mast cell progenitors to the lung is substantially reduced when CD11c(+) cells are depleted during the challenge phase. This correlated with an impaired induction of endothelial VCAM-1 and led to a significantly reduced number of mature mast cells 1 wk after challenge. Collectively, these data suggest that Ag challenge stimulates CD11c(+) cells to produce cytokines and/or chemokines required for VCAM-1 upregulation on the lung endothelium, which in turn is crucial for the Ag-induced mast cell progenitor recruitment and the increase in mast cell numbers.
Place, publisher, year, edition, pages
2012. Vol. 189, no 8, 3869-3877 p.
Immunology Immunology in the medical area
Research subject Immunology
IdentifiersURN: urn:nbn:se:uu:diva-184515DOI: 10.4049/jimmunol.1201200ISI: 000309590900014PubMedID: 22972929OAI: oai:DiVA.org:uu-184515DiVA: diva2:565594
FunderSwedish Research Council