uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
When to order a biopsy to characterise a metastatic relapse in breast cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Show others and affiliations
2012 (English)In: Annals of Oncology, ISSN 0923-7534, E-ISSN 1569-8041, Vol. 23, 349-353 p.Article in journal (Refereed) Published
Abstract [en]

Today, the diagnosis of metastatic breast cancer is usually based on radiological findings, and therapeutic decisions are made by considering the pathological characteristics and predictive markers of the primary tumour. Accumulating evidence suggests that tumour characteristics, including estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2), are unstable through tumour progression. Several retrospective studies and, recently, two prospective studies have investigated the discrepancies in receptor status between primary tumours and the corresponding metastases in a total of 1773 patients (for ER) and 2845 patients (for HER2). Changes in ER and HER2 status in these studies range from 14.5% to 40% and from 0% to 37.5%, respectively. In the two prospective studies, a different diagnosis, usually non-malignant, was obtained in 3% and 9% of the cases, and the biopsy led to a treatment modification in about one out of seven patients. Here, we review and discuss the currently available data and provide our recommendations on when a metastatic biopsy should be obtained.

Place, publisher, year, edition, pages
2012. Vol. 23, 349-353 p.
Keyword [en]
breast cancer, biopsy, heterogeneity, predictive biomarker
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-184656DOI: 10.1093/annonc/mds297ISI: 000309410600051OAI: oai:DiVA.org:uu-184656DiVA: diva2:567144
Available from: 2012-11-12 Created: 2012-11-12 Last updated: 2012-11-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Åström, Gunnar
By organisation
In the same journal
Annals of Oncology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 269 hits
ReferencesLink to record
Permanent link

Direct link