uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
d-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians
Show others and affiliations
2012 (English)In: European Archives of Psychiatry and Clinical Neuroscience, ISSN 0940-1334, E-ISSN 1433-8491, Vol. 262, no 7, 549-556 p.Article in journal (Refereed) Published
Abstract [en]

The d-amino acid oxidase activator (DAOA) protein regulates the function of d-amino oxidase (DAO), an enzyme that catalyzes the oxidative deamination of d-3,4-dihydroxyphenylalanine (D-DOPA) and d-serine. D-DOPA is converted to l-3,4-DOPA, a precursor of dopamine, whereas d-serine participates in glutamatergic transmission. We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Four single-nucleotide polymorphisms, previously reported to be associated with schizophrenia, were genotyped. Cerebrospinal fluid (CSF) samples were drawn by lumbar puncture, and the concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured. Two of the investigated polymorphisms, rs3918342 and rs1421292, were significantly associated with CSF HVA concentrations. Rs3918342 was found to be nominally associated with CSF 5-HIAA concentrations. None of the polymorphisms were significantly associated with MHPG concentrations. Our results indicate that DAOA gene variation affects dopamine turnover in healthy individuals, suggesting that disturbed dopamine turnover is a possible mechanism behind the observed associations between genetic variation in DAOA and behavioral phenotypes in humans.

Place, publisher, year, edition, pages
2012. Vol. 262, no 7, 549-556 p.
Keyword [en]
D-amino acid oxidase activator gene (DAOA), Cerebrospinal fluid (CSF), Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG)
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-184639DOI: 10.1007/s00406-012-0313-zISI: 000309561800003OAI: oai:DiVA.org:uu-184639DiVA: diva2:567331
Available from: 2012-11-12 Created: 2012-11-12 Last updated: 2012-11-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Hall, Håkan
By organisation
GeriatricsPreclinical PET Platform
In the same journal
European Archives of Psychiatry and Clinical Neuroscience
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 270 hits
ReferencesLink to record
Permanent link

Direct link