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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2012 (English)In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 17, no 15-16, 905-912 p.Article, review/survey (Refereed) Published
Abstract [en]

Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization.

Place, publisher, year, edition, pages
2012. Vol. 17, no 15-16, 905-912 p.
Keyword [en]
membrane permeation assay, central-nervous-system, pept1 knockout mice, neutral amino-acid, lipid-bilayers, p-glycoprotein, artificial membranes, hydrophilic pores, transient pores, caco-2 cells
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-184773DOI: 10.1016/j.drudis.2012.03.015ISI: 000308048800014OAI: oai:DiVA.org:uu-184773DiVA: diva2:567749
Available from: 2012-11-14 Created: 2012-11-13 Last updated: 2017-12-07Bibliographically approved

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Artursson, PerLennernäs, Hans

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