Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
2012 (English)In: Nature and Science of Sleep, ISSN 1179-1608, Vol. 4, 89-96 p.Article in journal (Refereed) Published
Objective: The objective of this study was to evaluate the effect of oral appliance (OA) treatment on cognitive functions in patients with obstructive sleep apnea (OSA). Materials and methods: In a prospective study, 50 male patients with verified moderate-to-severe OSA received an OA with mandibular advancement. The cognitive functions assessed included working memory, vigilance, executive functioning, and mental pace, measured before as well as after 6 months of treatment. Somnography was used to measure physiological treatment effects. Forty-three patients completed the 6-month follow-up study. Results: All domains of cognitive functioning measured improved after 6 months of treatment with an OA (P < 0.001). The apnea/hypopnea- and oxygen desaturation-indices decreased significantly after treatment (P < 0.01). An obvious treatment response was reached in 60% of the patients, and 54% of the patients had recovered ie, had normalized breathing during sleep. Conclusion: OA with mandibular advancement is a treatment modality for the physiological symptoms of OSA, and may have a positive impact on cognitive functions, after only 6 months of treatment.
Place, publisher, year, edition, pages
2012. Vol. 4, 89-96 p.
Clinical trial, Cognition, Oral appliance, Sleep apnea, Treatment
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-184924DOI: 10.2147/NSS.S33849OAI: oai:DiVA.org:uu-184924DiVA: diva2:570501