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Update on levodopa/carbidopa intestinal gel infusion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
2012 (English)In: European Neurological Review, ISSN 1758-3837, Vol. 7, no SUPPL.1, 13-16 p.Article in journal (Refereed) Published
Abstract [en]

Recent data on levodopa/carbidopa intestinal gel (LCIG) infusion are discussed in this article. LCIG infusion provides improvements in 'off' time and dyskinesia via continuous dopaminergic stimulation (CDS). In the long-term, LCIG infusion appears to maintain efficacy without the need to increase dosages. The growing number of publications on LCIG infusion shows the increasing experience and interest in this therapy. The new data demonstrate the effects of using LCIG infusion in combination with catechol-O-methyl transferase inhibitors, and technical improvements to the pump system (e.g., to the tubing). Despite the invasive nature of LCIG infusion, nearly all patients would recommend this treatment. Furthermore, a number of larger-scale studies on this particular CDS therapy are in progress.

Place, publisher, year, edition, pages
2012. Vol. 7, no SUPPL.1, 13-16 p.
Keyword [en]
Continuous dopaminergic stimulation, Levodopa, Levodopa/carbidopa intestinal gel, Motor fluctuations, Parkinson's disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-184918OAI: oai:DiVA.org:uu-184918DiVA: diva2:570517
Available from: 2012-11-19 Created: 2012-11-15 Last updated: 2014-09-10Bibliographically approved

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Nyholm, Dag

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