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TGF-β signalling and its role in cancer progression and metastasis
Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
2012 (English)In: Cancer Metastasis Review, ISSN 0167-7659, E-ISSN 1573-7233, Vol. 31, no 3-4, 553-568 p.Article, review/survey (Refereed) Published
Abstract [en]

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-β signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-β acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-β signalling pathway, its involvement in cancer and current therapeutic approaches.

Place, publisher, year, edition, pages
2012. Vol. 31, no 3-4, 553-568 p.
Keyword [en]
Cancer, Epithelial to mesenchymal transition, SMAD, TGF-β signalling
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-184880DOI: 10.1007/s10555-012-9375-7ISI: 000309863800012OAI: oai:DiVA.org:uu-184880DiVA: diva2:570949
Available from: 2012-11-21 Created: 2012-11-15 Last updated: 2017-12-07Bibliographically approved

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ten Dijke, Peter

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