TGF-β signalling and its role in cancer progression and metastasis
2012 (English)In: Cancer Metastasis Review, ISSN 0167-7659, E-ISSN 1573-7233, Vol. 31, no 3-4, 553-568 p.Article, review/survey (Refereed) Published
The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-β signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-β acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-β signalling pathway, its involvement in cancer and current therapeutic approaches.
Place, publisher, year, edition, pages
2012. Vol. 31, no 3-4, 553-568 p.
Cancer, Epithelial to mesenchymal transition, SMAD, TGF-β signalling
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-184880DOI: 10.1007/s10555-012-9375-7ISI: 000309863800012OAI: oai:DiVA.org:uu-184880DiVA: diva2:570949