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Extended NO analysis in health and disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
2012 (English)In: Journal of breath research, ISSN 1752-7163, Vol. 6, no 4, 047103- p.Article in journal (Refereed) Published
Abstract [en]

Extended NO analysis is a promising tool in different diseases where NO metabolism is altered. One single exhalation cannot give insight to the NO production in the respiratory system; rather the use of multiple exhalation flows can give the alveolar levels (CANO), airway wall concentration (CawNO) and the diffusion rate of NO (DawNO). Increased values of CANO are shown in COPD, systemic sclerosis, hepatopulmonary syndrome and in severe asthma. In asthma the CawNO and DawNO are increased leading to an increase in bronchial NO flux (J'awNO). Low levels of J'awNO are seen in cystic fibrosis, primary ciliary dyskinesia and in smoking subjects. More studies are needed to evaluate the clinical usefulness of the extended NO analysis, similar to what has been done in systemic sclerosis where a cut-off value has been identified predicting pulmonary function deterioration.

Place, publisher, year, edition, pages
2012. Vol. 6, no 4, 047103- p.
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-185325DOI: 10.1088/1752-7155/6/4/047103ISI: 000311845300011PubMedID: 22677778OAI: oai:DiVA.org:uu-185325DiVA: diva2:571276
Available from: 2012-11-22 Created: 2012-11-22 Last updated: 2013-01-10Bibliographically approved

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Högman, Marieann
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Respiratory Medicine and AllergologyCentre for Research and Development, Gävleborg
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