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Interim analysis of long-term intraduodenal levodopa infusion in advanced Parkinson disease
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2012 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 126, no 6, e29-e33 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This interim 12-month analysis is a part of an open-label, observational, prospective study on health outcomes and cost impact of levodopa/carbidopa intestinal gel (LCIG, Duodopa) in Parkinson disease (PD). The specific aim was to investigate clinical and health-related quality of life (HRQoL) effects in routine care.

METHODS: Unified PD rating scale (UPDRS) was the primary efficacy measurement. PD QoL questionnaire 39 (PDQ-39) assessed HRQoL. Subjects were assessed at baseline, ≥3 months after surgery, and then every 3 months.

RESULTS: Twenty-seven treatment-naïve subjects when started with LCIG showed a decrease in UPDRS score that was statistically significant throughout the year: UPDRS total score (mean ± SD), baseline = 52.1 ± 16.1, N = 27, month 0 (first visit; at least 3 months after permanent LCIG) = 43.1 ± 16.7, N = 27, P = 0.003; month 12 = 42.5 ± 22.6, n = 25, P = 0.017. PDQ-39 results also showed a tendency for improvement: PDQ-39 (mean ± SD), baseline = 33.6 ± 10.8, N = 27, month 0 = 27.1 ± 11.8, N = 27, P = 0.001; 12 months = 28.8 ± 12.8, n = 23, P = 0.126.

CONCLUSIONS: LCIG provides functional improvement beginning at first visit that is sustained for 12 months.

Place, publisher, year, edition, pages
2012. Vol. 126, no 6, e29-e33 p.
National Category
Neurology
Research subject
Neurology
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URN: urn:nbn:se:uu:diva-185433DOI: 10.1111/j.1600-0404.2012.01689.xISI: 000310545400001PubMedID: 22690905OAI: oai:DiVA.org:uu-185433DiVA: diva2:571749
Available from: 2012-11-23 Created: 2012-11-23 Last updated: 2017-12-07Bibliographically approved

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Nyholm, DagJohansson, Anders

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