uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis
Show others and affiliations
2012 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 41, no 5, 1419-1433 p.Article in journal (Refereed) Published
Abstract [en]

Background

The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

Methods

We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.

Results

For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

Conclusion

Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

Place, publisher, year, edition, pages
2012. Vol. 41, no 5, 1419-1433 p.
Keyword [en]
Height, cardiovascular disease, cancer, cause-specific mortality, epidemiological study, meta-analysis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-185514DOI: 10.1093/ije/dys086ISI: 000309922700028PubMedID: 22825588OAI: oai:DiVA.org:uu-185514DiVA: diva2:571979
Note

Karl Michaëlsson (Department of Surgical Sciences, Orthopaedics, Uppsala University, Sweden) contributed to this study.

Available from: 2012-11-26 Created: 2012-11-26 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Svärdsudd, KurtSundström, Johan

Search in DiVA

By author/editor
Svärdsudd, KurtSundström, Johan
By organisation
Family Medicine and Preventive MedicineCardiovascular epidemiology
In the same journal
International Journal of Epidemiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 434 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf