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A graphene field-effect capacitor sensor in electrolyte
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
Shenyang National Laboratory, Kina.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
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2012 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 101, no 15, 154106- p.Article in journal, Letter (Refereed) Published
Abstract [en]

The unique electronic properties of graphene are exploited for field-effect sensing in both capacitor and transistor modes when operating the sensor device in electrolyte. The device is fabricated using large-area graphene thin films prepared by means of layer-by-layer stacking. Although essentially the same device, its operation in the capacitor mode is found to yield more information than in the transistor mode. The capacitor sensor can simultaneously detect the variations of surface potential and electrical-double-layer capacitance at the graphene/electrolyte interface when altering the ion concentration. The capacitor-mode operation further facilitates studies of the molecular binding-adsorption kinetics by monitoring the capacitance transient

Place, publisher, year, edition, pages
2012. Vol. 101, no 15, 154106- p.
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Nano Technology
Research subject
Engineering Science with specialization in Electronics
Identifiers
URN: urn:nbn:se:uu:diva-185550DOI: 10.1063/1.4759147ISI: 000310304900106OAI: oai:DiVA.org:uu-185550DiVA: diva2:572068
Available from: 2012-11-26 Created: 2012-11-26 Last updated: 2017-12-07
In thesis
1. Electronic Sensors Based on Nanostructured Field-Effect Devices
Open this publication in new window or tab >>Electronic Sensors Based on Nanostructured Field-Effect Devices
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Point-of-care (POC) diagnostics presents a giant market opportunity with profound societal impact. In particular, specific detection of DNA and protein markers can be essential for early diagnosis of e.g. cancer, cardiovascular disease, infections or allergies. Today, identification of these markers often requires extensive laboratory work and hence is expensive and time consuming. Current methods for recognition and detection of specific biomolecules are mostly optics based and thus impose severe limitations as to convenience, specificity, sensitivity, parallel processing and cost reduction.

Electronic sensors based on silicon nanowire field-effect transistors have been reported to be able to detect biomolecules with concentrations down to femtomolar (fM) level with high specificity. Although the reported capability needs further confirmation, the CMOS-compatible fabrication process of such sensors allows for low cost production and high density integration, which are favorable for POC applications. This thesis mainly focuses on the development of a multiplex detection platform based on silicon nanowire field-effect sensors integrated with a microfluidic system for liquid sample delivery. Extensive work was dedicated to developing a top-down fabrication process of the sensors as well as an effective passivation scheme. The operation mechanism and coupling efficiencies of different gate configurations were studied experimentally with the assistance of numerical simulation and equivalent circuits. Using pH sensing as a model system, large effort was devoted to identifying sources for false responses resulting from the instability of the inert-metal gate electrode. In addition, the drift mechanism of the sensor operating in electrolyte was addressed and a calibration model was proposed. Furthermore, protein detection experiments were performed using small-sized Affibody molecules as receptors on the gate insulator to tackle the Debye screening issue. Preliminary results showed that the directionality of the current changes in the sensors was in good agreement with the charge polarities of the proteins. Finally, a graphene-based capacitor was examined as an alternative to the nanowire device for field-effect ion sensing. Our initial attempts showed some attractive features of the capacitor sensor.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2013. 71 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1018
Keyword
biosensor, field-effect transistor, nanowire, ISFET
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Nano Technology
Research subject
Electronics
Identifiers
urn:nbn:se:uu:diva-194015 (URN)978-91-554-8596-2 (ISBN)
Public defence
2013-03-27, Häggsalen, Ångström Laboratory, Lägerhyddsvägen 1, Uppsala, 10:00 (English)
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Supervisors
Available from: 2013-03-05 Created: 2013-02-07 Last updated: 2013-04-02Bibliographically approved

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Chen, SiZhang, Zhi-BinAhlberg, PatrikGao, XindongZhang, Shili

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