Gamma-Hydroxybutyrate (GHB) induces cognitive deficits and affects GABAB receptors and IGF-1 receptors in male rats
2014 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 269, 164-174 p.Article in journal (Refereed) Published
In recent years, the abuse of the club drug Gamma-hydroxy butyric acid (GHB) has become increasingly frequent among adolescents. The drug induces euphoria but can also result in sedation, anaesthesia as well as short-term amnesia. In addition, the abuse of GHB is reported to cause cognitive impairments. The mechanism by which GHB induces impairment in learning and memory has not been fully clarified. The present study investigates the impact on spatial learning and memory using a water maze test in rats treated with GHB. The behavioural data is combined with an autoradiographic analysis of the GABAB and the IGF-1 receptor systems. The results demonstrate that the GHB treated animals display an impaired performance in the water maze test as compared to controls. In addition, significant alterations in GABAB and IGF-1 receptor density as well as GABAB receptor functionality, were observed in several brain regions associated with cognitive functions e.g. hippocampus. To conclude, our findings suggest that GHB treatment can affect spatial learning and memory, and that this outcome at least to some extent is likely to involve both GABAB and IGF-1 receptors.
Place, publisher, year, edition, pages
2014. Vol. 269, 164-174 p.
Gamma-hydroxybutyrate (GHB), GABAB and IGF-1 receptors, Autoradiography, GTPgammaS-assay, Rat, Central nervous system (CNS).
Research subject Biological Research on Drug Dependence
IdentifiersURN: urn:nbn:se:uu:diva-185421DOI: 10.1016/j.bbr.2014.04.034ISI: 000337866400021OAI: oai:DiVA.org:uu-185421DiVA: diva2:572269
FunderSwedish Research Council, 9459