Viral and Molecular Aspects of Oral Cancer
2012 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 32, no 10, 4201-4212 p.Article, review/survey (Refereed) Published
Squamous cell carcinoma (SCC) is the most common epithelial malignancy in the oral cavity. SCCs and their variants constitute over 90% of oral malignancies, and the disease is associated with poor prognosis. OSCC is a complex malignancy where environmental factors, virus infections, and genetic alterations most likely interact, and thus give rise to the malignant condition. Herein, we review the available literature regarding high-risk factors such as alcohol and tobacco usage; discuss the roles of human papillomaviruses (HPV), the Epstein-Barr virus, and the human herpes simplex virus (HSV); and evaluate several candidate genes associated with the condition: p53, p16(INK4) and p21(WAF1/CIP1) survivin, B-cell lymphoma-2 (BCL-2), keratins, Fibroblast growth factor 3 (FGF3), FGF4, FGF19, Oral cancer overexpressed gene 1 (ORAOV1), and Cyclin D1 (CCND1).
Place, publisher, year, edition, pages
2012. Vol. 32, no 10, 4201-4212 p.
Oral cancer, tobacco, HPV, EBV, HSV-1, p53, p16(INK4A) and p21(WAF1/CIP1), survivin, BCL-2, keratins, FGF3, FGF4, FGF19, ORAOV1, CCND1, review
Cancer and Oncology Surgery
IdentifiersURN: urn:nbn:se:uu:diva-185673ISI: 000310111800003PubMedID: 23060540OAI: oai:DiVA.org:uu-185673DiVA: diva2:572380