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Viral and Molecular Aspects of Oral Cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
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2012 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 32, no 10, 4201-4212 p.Article, review/survey (Refereed) Published
Abstract [en]

Squamous cell carcinoma (SCC) is the most common epithelial malignancy in the oral cavity. SCCs and their variants constitute over 90% of oral malignancies, and the disease is associated with poor prognosis. OSCC is a complex malignancy where environmental factors, virus infections, and genetic alterations most likely interact, and thus give rise to the malignant condition. Herein, we review the available literature regarding high-risk factors such as alcohol and tobacco usage; discuss the roles of human papillomaviruses (HPV), the Epstein-Barr virus, and the human herpes simplex virus (HSV); and evaluate several candidate genes associated with the condition: p53, p16(INK4) and p21(WAF1/CIP1) survivin, B-cell lymphoma-2 (BCL-2), keratins, Fibroblast growth factor 3 (FGF3), FGF4, FGF19, Oral cancer overexpressed gene 1 (ORAOV1), and Cyclin D1 (CCND1).

Place, publisher, year, edition, pages
2012. Vol. 32, no 10, 4201-4212 p.
Keyword [en]
Oral cancer, tobacco, HPV, EBV, HSV-1, p53, p16(INK4A) and p21(WAF1/CIP1), survivin, BCL-2, keratins, FGF3, FGF4, FGF19, ORAOV1, CCND1, review
National Category
Cancer and Oncology Surgery
Identifiers
URN: urn:nbn:se:uu:diva-185673ISI: 000310111800003PubMedID: 23060540OAI: oai:DiVA.org:uu-185673DiVA: diva2:572380
Available from: 2012-11-27 Created: 2012-11-27 Last updated: 2017-12-07Bibliographically approved

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Hillbertz, Nicolette SalmonHirsch, Jan-MichaelJalouli, JamshidJalouli, Miranda M.Sand, Lars

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