Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes
2012 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 287, no 44, 37508-37521 p.Article in journal (Refereed) Published
Background: Ribosomal PTC acts as a protein folding modulator in vivo and in vitro. Results: A fixed set of nucleotides in the PTC interacts to fold polypeptides in vivo and in vitro. Conclusion: Folding all proteins through interaction with the same set of nucleotides in PTC implies they have intrinsic homology. Significance: Hundreds of proteins showed an identical cumulative hydrophobicity plot for amino acids.
Place, publisher, year, edition, pages
2012. Vol. 287, no 44, 37508-37521 p.
IdentifiersURN: urn:nbn:se:uu:diva-186036DOI: 10.1074/jbc.M112.396127ISI: 000310588500079OAI: oai:DiVA.org:uu-186036DiVA: diva2:572546