uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
No association between infections, HLA type and other transplantrelated factors and risk of cutaneous squamous cell carcinoma in solid organ transplant recipients
Show others and affiliations
2012 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 92, no 6, 609-614 p.Article in journal (Refereed) Published
Abstract [en]

Recipients of solid organ transplants are at a markedly increased risk of cutaneous squamous cell carcinoma (SCC). We investigated potential associations between post-transplant infections, HLA type, and other transplant-related factors and risk of SCC, taking immunosuppressive treatment into account. A population-based case-control study was conducted. All patients who developed SCC during follow-up (1970-1997) were eligible as cases (n = 207). Controls (n = 189) were individually matched to the cases on age and calendar period of transplantation. Detailed exposure information was collected through an extensive, blinded review of medical records. Odds ratios were computed with conditional logistic regression. There were no significant associations with any infectious agents, or with number and timing of infections, specific HLA-type, donor characteristics, or other transplant characteristics and risk of post-transplant SCC. These results suggest that risk of post-transplant SCC is neither closely related to specific post-transplant infectious disorders, nor to the infectious load or specific HLA types.

Place, publisher, year, edition, pages
2012. Vol. 92, no 6, 609-614 p.
Keyword [en]
Carcinoma, Case-control study, HLA antigens, Infection, Organ transplantation, Squamous cell
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-186033DOI: 10.2340/00015555-1271ISI: 000310828300009OAI: oai:DiVA.org:uu-186033DiVA: diva2:572550
Available from: 2012-11-28 Created: 2012-11-27 Last updated: 2013-02-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Tufveson, Gunnar
By organisation
Transplantation Surgery
In the same journal
Acta Dermato-Venereologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 291 hits
ReferencesLink to record
Permanent link

Direct link