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Comparing different identification approaches for the depth of anesthesia using BIS measurements
Departamento de Matematica, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal.
CIDMA, Center for Research and Developments in Mathematics and Applications, Aveiro, Portugal.
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
Centro Hospitalar do Porto, Hospital Geral de Santo Antonio, Porto, Portugal.
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2012 (English)In: Proc. 16th IFAC Symposium on System Identification, 2012, 781-785 p.Conference paper, Published paper (Refereed)
Abstract [en]

Depth of anesthesia is usually quantified by the Bispectral Index (BIS) and refers to both loss of consciousness, resulting from the administration of a hypnotic like propofol, and inhibition of pain, resulting from the administration of an analgesic like remifentanil. This paper addresses the mathematical modeling of the joint effect of propofol and remifentanil in the depth of anesthesia, using BIS measurements. Two models and identification strategies are considered. The first model is based on standard pharmacokinetic/pharmacodynamic models and the associated identification strategy corresponds to the application of a hybrid method. The second model has a minimal number of parameters and the associated identification strategy corresponds to the application of a prediction error method. These two approaches are tested and compared on real data.

Place, publisher, year, edition, pages
2012. 781-785 p.
National Category
Control Engineering
Identifiers
URN: urn:nbn:se:uu:diva-186970OAI: oai:DiVA.org:uu-186970DiVA: diva2:573424
Conference
16th IFAC Symposium on System Identification
Available from: 2012-11-30 Created: 2012-11-30 Last updated: 2012-12-01

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Martins da Silva, Margarida

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