Control of rocuronium-induced neuromuscular blockade via online identification of a two-parameters Wiener model
2012 (English)In: Proc. 16th IFAC Symposium on System Identification, 2012, 571-576 p.Conference paper (Refereed)
A closed-loop controller for rocuronium-induced neuromuscular blockade using the first twitch of a train-of-four electromyographic stimulation as the measured signal is presented. Central to this development is the use of a two-parameters Wiener model, previously proposed toatracurium. The controller includes recursive parameters identification by an EKF, inversion of the nonlinearity using the current nonlinear parameter estimate and a pole placement controller for the exactly linearized system. Numerical tests on the performance of this adaptive structure were carried out on a bank of 500 simulated standard PK/PD models. The developed controller steers the neuromuscular blockade to a desired reference, tracking a constant or varying profile.It is also able to deal with parameter-varying systems and works well in noisy scenarios. These capabilities are crucial when testing this structure in a real clinical environment.
Place, publisher, year, edition, pages
2012. 571-576 p.
IdentifiersURN: urn:nbn:se:uu:diva-186973OAI: oai:DiVA.org:uu-186973DiVA: diva2:573426
16th IFAC Symposium on System Identification