Adaptive control of propofol-induced hypnosis in anesthesia using a minimally parameterized Wiener model
2012 (English)In: Proc. Reglermöte, 2012Conference paper (Other academic)
An adaptive controller for propofol administration in anesthesia is proposed in this paper. The controller design relies on a minimally parameterized SISO Wiener model for the anesthetic effect. The exact linearization of this minimal Wiener structure using the continuous-time model parameter estimates calculated online by an extended Kalman filter is a key point in the design. A linear quadratic Gaussian controller is developed for the exactly linearized system. Excellent results were obtained when the robustness of the proposed controller was assessed with respect to inter and intrapatient variability through simulations on a database of 500 patients, irrespective of which index that was used to measure the anesthetic effect: bispectral index, state entropy and response entropy.
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IdentifiersURN: urn:nbn:se:uu:diva-186974OAI: oai:DiVA.org:uu-186974DiVA: diva2:573431