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Beneficial Effect of Interleukin 1 Inhibition with Anakinra in Adult-onset Still's Disease. An Open, Randomized, Multicenter Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
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2012 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 39, no 10, 2008-2011 p.Article in journal (Refereed) Published
Abstract [en]

Objective. To study the efficacy of anakinra versus disease-modifying antirheumatic drugs (DMARD) in refractory adult-onset Still's disease (AOSD). Methods. In a 24-week study, 22 patients with AOSD taking prednisolone >= 10 mg/day received anakinra (n = 12) or DMARD (n = 10). The primary endpoint was achievement of remission. Results. At 8 and 24 weeks, 7/12 and 6/12 receiving anakinra and 5/10 and 2/10 receiving DMARD achieved remission. Anakinra induced greater improvement in physical health measured by Medical Outcomes Study Short-Form 36 (SF-36; p < 0.011). During an open-label extension (OLE) of 28 weeks, 7/14 patients taking anakinra and 2/3 taking DMARD were in remission. Conclusion. Anakinra induced more beneficial responses than DMARD in patients with AOSD and was favored in the OLE phase. (ClinicalTrials.gov Protocol Registration NCT01033656).

Place, publisher, year, edition, pages
2012. Vol. 39, no 10, 2008-2011 p.
Keyword [en]
adult-onset still's disease, anakinra, interleukin 1, randomized, multicenter, Wissler's syndrome
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-187100DOI: 10.3899/jrheum.111549ISI: 000310256100016OAI: oai:DiVA.org:uu-187100DiVA: diva2:574062
Available from: 2012-12-04 Created: 2012-12-03 Last updated: 2017-12-07Bibliographically approved

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