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Alcohol Consumption Among Pregnant Women in a Swedish Sample and Its Effects on the Newborn Outcomes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Gynekologisk endokrinologi/Naessén)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
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2012 (English)In: Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, E-ISSN 1530-0277, Vol. 36, no 10, 1779-1786 p.Article in journal (Refereed) Published
Abstract [en]

Background Little is known about the effects of low levels of maternal alcohol intake on the neuropsychological development of the child. This study is part of an ongoing investigation on maternal drinking and presents data on demographic variables, maternal alcohol use, and birth outcomes from that study. Methods The sample comprised 2,264 women from a Swedish antenatal clinic. Retrospective self-report data were collected on alcohol consumption before and during pregnancy, using the Alcohol Use Disorders Identification Test (AUDIT), and on nicotine use. Specific alcohol biomarkers for excessive drinking, carbohydrate-deficient transferrin (CDT) in serum and phosphatidylethanol (PEth) in whole blood, were determined during mid-pregnancy in a subsample of the women. Data on labor and early characteristics of the child were also assessed. Results Before pregnancy, 89% of the women regularly consumed alcohol and 49% reported occasional or frequent binge drinking. Nicotine was used by 15% before and by 5% during pregnancy. During pregnancy, 12% continued using alcohol and 5% also admitted binge drinking. However, all alcohol biomarker values were below the reporting limits (CDT = 1.7% disialotransferrin; total PEth < 0.1 mu mol/L). Self-reported drinking during pregnancy was associated with a higher AUDIT score before pregnancy, nicotine use at the time of the first prenatal visit, older age, and previous legal abortions. Conclusions The AUDIT questionnaire and 2 specific alcohol biomarkers were used in routine maternity care to collect information about drinking during pregnancy and thereby to identify children at risk for alcohol-related complications. While the AUDIT results suggested that a significant number of women continued using alcohol during pregnancy, implying a risk for fetal disorders, the biomarkers showed negative test values thus indicating only modest drinking levels.

Place, publisher, year, edition, pages
2012. Vol. 36, no 10, 1779-1786 p.
Keyword [en]
Alcohol, AUDIT, Pregnancy, CDT, PEth, Women
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-187095DOI: 10.1111/j.1530-0277.2012.01783.xISI: 000309390800012OAI: oai:DiVA.org:uu-187095DiVA: diva2:574077
Available from: 2012-12-04 Created: 2012-12-03 Last updated: 2017-12-07Bibliographically approved

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Comasco, ErikaHallberg, GunillaOreland, LarsSundelin Wahlsten, Viveka

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Comasco, ErikaHallberg, GunillaOreland, LarsSundelin Wahlsten, Viveka
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Neuro-psycho-pharmacologyDepartment of Women's and Children's HealthChild and Adolescent Psychiatry
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Alcoholism: Clinical and Experimental Research
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