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Prenatal characteristics of infants with a neuronal migration disorder: a national-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Perinatal, neonatal och barnkardiologisk forskning/Hellström Westas)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Barnneurologisk forskning/Ahlsten)
Department of Medicine, Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden.
2012 (English)In: International journal of pediatrics, ISSN 1687-9759, Vol. 2012, 541892- p.Article in journal (Refereed) Published
Abstract [en]

The development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both genetic and environmental factors. Few epidemiological studies have addressed the impact of prenatal exposures. All infants born alive and included in the Swedish Medical Birth Register 1980-1999 were included in the study. By linkage to the Patient Register, 820 children with a diagnosis related to a neuronal migration abnormality were identified. Through copies of referrals for computer tomography or magnetic resonance imaging of the brain, the diagnosis was confirmed in 17 children. Median age of the mothers was 29 years. At the start of pregnancy, four out of 17 women smoked. Almost half of the women had a body mass index that is low or in the lower range of average. All infants were born at term with normal birth weights. Thirteen infants had one or more concomitant diseases or malformations. Two infants were born with rubella syndrome. The impact of low maternal body mass index and congenital infections on neuronal migration disorders in infants should be addressed in future studies.

Place, publisher, year, edition, pages
2012. Vol. 2012, 541892- p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-187290DOI: 10.1155/2012/541892PubMedID: 22548087OAI: oai:DiVA.org:uu-187290DiVA: diva2:574143
Available from: 2012-12-04 Created: 2012-12-04 Last updated: 2012-12-04Bibliographically approved

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Naumburg, EstelleStrömberg, Bo

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