uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Type I Interferons in Sjögren's Syndrome
Show others and affiliations
2013 (English)In: Autoimmunity Reviews, ISSN 1568-9972, E-ISSN 1873-0183, Vol. 12, no 5, 558-566 p.Article, review/survey (Refereed) Published
Abstract [en]

Sjögren's syndrome is a chronic autoimmune disease characterized by lymphocytic infiltration of the salivary and lachrymal glands resulting in dry eyes and mouth. Genetic predisposition, pathogenic infections and hormones have been implicated in the pathogenesis of the disease. Studies in the last several years have revealed marked over-expression of the type I interferon (IFN) -inducible genes in the peripheral blood and salivary glands of patients with Sjögren's syndrome. The expression of the type I IFN-inducible genes in Sjögren's syndrome also positively correlates to titers of anti-Ro and anti-La autoantibodies, which are typical for this disease. Plasmacytoid dendritic cells (pDC) are the major source of type I IFN production and activated pDC are detected in minor salivary gland biopsies from patients with primary Sjögren's syndrome. In addition, polymorphisms in genes important both for the production and response to type I IFN are associated to increased risk for Sjögren's syndrome. Because type I IFN bears a variety of biological functions, such as defense against viral infections and activation of the immune system, these results suggest that the type I IFN system have an important role in the pathogenesis of Sjögren's syndrome. A variety of mechanisms causing an activation of the type I IFN system are discussed in this review. Given the pivotal role of type I IFN in the disease process, therapeutic interventions targeting the type I IFN signaling pathway have the potential to benefit the patients with elevated type I IFN status and such hypothesis needs to be carefully evaluated in clinical development.

Place, publisher, year, edition, pages
2013. Vol. 12, no 5, 558-566 p.
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:uu:diva-187467DOI: 10.1016/j.autrev.2012.10.006ISI: 000316531100003PubMedID: 23201923OAI: oai:DiVA.org:uu-187467DiVA: diva2:574825
Available from: 2012-12-06 Created: 2012-12-06 Last updated: 2013-04-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Rönnblom, Lars
By organisation
In the same journal
Autoimmunity Reviews
Rheumatology and Autoimmunity

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 191 hits
ReferencesLink to record
Permanent link

Direct link