Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold
2012 (English)In: Chemistry and Biodiversity, ISSN 1612-1872, E-ISSN 1612-1880, Vol. 9, no 11, 2442-2452 p.Article in journal (Refereed) Published
In this study, we explored the effect of bioisostere replacement in a series of glycogen synthase kinase 3 (GSK3) inhibitors based on the imidazopyridine core. The synthesis and biological evaluation of a number of novel sulfonamide, 1,2,4-oxadiazole, and thiazole derivates as amide bioisosteres, as well as a computational rationalization of the obtained results are reported.
Place, publisher, year, edition, pages
2012. Vol. 9, no 11, 2442-2452 p.
Medical and Health Sciences Medicinal Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-187797DOI: 10.1002/cbdv.201200308ISI: 000311299400006PubMedID: 23161627OAI: oai:DiVA.org:uu-187797DiVA: diva2:575629