Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions
2012 (English)In: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, ISSN 0936-5214, E-ISSN 1437-2096, no 5, 685-698 p.Article in journal (Refereed) Published
This Account summarizes predominately our own experiences in developing microwave-heated palladium-catalyzed Mo(CO)6-mediated gas-free carbonylative reactions, although contributions from other groups, including non-palladium-catalyzed examples, have also been covered. Presented reactions include amino-, amido-, and alkoxycarbonylations as well as carbonylative cyclizations and carbonylative cross-couplings, using Mo(CO)6 as a solid source of CO. The methodology was developed mainly for rapid small-scale applications, avoiding the problematic use of gaseous CO in a standard laboratory. In most cases, the reported Mo(CO)6-mediated carbonylations were conducted in sealed vessels and with reaction times of less than 1 hour. The Account also highlights relevant applications in medicinal and high-speed chemistry.
Place, publisher, year, edition, pages
2012. no 5, 685-698 p.
carbonylation, molybdenum, multicomponent reaction, palladium, catalysis
Medical and Health Sciences Medicinal Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-187859DOI: 10.1055/s-0031-1290350ISI: 000301343400003OAI: oai:DiVA.org:uu-187859DiVA: diva2:575742
Dedicated to Prof. Anders Hallberg on the occasion of his 67th birthday2012-12-112012-12-112015-05-26Bibliographically approved