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The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
2012 (English)In: Obesity Reviews, ISSN 1467-7881, E-ISSN 1467-789X, Vol. 13, no 12, 1096-1109 p.Article, review/survey (Refereed) Published
Abstract [en]

In 2007, the first common genetic variants were identified, which undoubtedly affect our susceptibility to obesity. These variants are located in the fat mass and obesity-associated gene FTO. Since then, over 50 loci for common obesity have been identified. As the research on these loci is still at an early stage, there is a great need to review, for clarification purposes, the current research on FTO, as this is likely to influence future studies. Based on the current knowledge, FTO seems to be directly involved in the regulation of energy intake, but there is an urgent need for the identification of regulatory polymorphisms. Thus, herein, we discuss current knowledge and highlight putative functional regions in FTO based on published data and computer-based analysis.

Place, publisher, year, edition, pages
2012. Vol. 13, no 12, 1096-1109 p.
Keyword [en]
FTO, obesity, SNP
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-187835DOI: 10.1111/j.1467-789X.2012.01025.xISI: 000310676800002OAI: oai:DiVA.org:uu-187835DiVA: diva2:575857
Available from: 2012-12-11 Created: 2012-12-11 Last updated: 2017-12-07Bibliographically approved

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Jacobsson, Josefin A.Schioth, Helgi B.Fredriksson, Rorbert

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