uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Anti-citrullinated peptide antibodies and rheumatoid factor in Sudanese patients with Leishmania donovani infection
Show others and affiliations
2011 (English)In: REV BRAS REUMATOL, ISSN 0482-5004, Vol. 51, no 6, 572-586 p.Article in journal (Refereed) Published
Abstract [en]

Objective: The present study evaluated the presence of anti-cyclic citrullinated peptides antibodies (anti-CCP), rheumatoid factor (RF), and circulating immune complexes (CIC) in Sudanese patients infected with the Leishmania donovani parasite. Patients and methods: Sera were collected from Leishmania infected patients (n = 116) and healthy Sudanese (n = 93). Nineteen Sudanese anti-CCP+RA patients were included as positive controls. Levels of CIC and anti-CCP were measured by ELISA. Control plate with cyclic control peptides containing arginine instead of citrulline was used to evaluate citrulline specific reactivity. Results: Among Leishmania-infected patients and anti-CCP+RA patients, most were RF positive (86%), while the frequency of CIC positivity was higher among visceral leishmaniasis (VL) patients (VL 38%; anti-CCP+RA 24%). When anti-CCP reactivity was analysed, 12% of VL patients were found to be positive. The levels of anti-CCP among V L patients correlated well with the CIC levels found (r = 0.65, P < 0.0001). In RA group, no association was found between CIC and anti-CCP. The possibility that anti-CCP positivity was due to cross reactions with CIC was experimentally ruled out. Contrary to what was seen in Sudanese RA sera, the CCP reactivity was not restricted to citrulline but reacted equally well with the arginine control peptide. Conclusion: The finding that CCP reactivity was not restricted to citrulline argues that this is more an effect of extensive inflammation and immune activation than a sign of shared pathogenic characteristics with anti-CCP arthritis. Our findings stress the importance to interpret a positive CCP test carefully when evaluated in non-rheumatic conditions or in areas where such infections predominate.

Place, publisher, year, edition, pages
2011. Vol. 51, no 6, 572-586 p.
Keyword [en]
rheumatoid factor, Leishmania donovani, antigen-antibody complex
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-179238ISI: 000306258700005OAI: oai:DiVA.org:uu-179238DiVA: diva2:576461
Note

This article has been retracted.

See: Anti-citrullinated peptide antibodies and rheumatoid factor in Sudanese patients with Leishmania donovani infection (vol 51, pg 579, 2011) DOI: 10.1016/j.rbre.2014.05.002

Available from: 2012-12-13 Created: 2012-08-10 Last updated: 2016-12-21Bibliographically approved

Open Access in DiVA

No full text

Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 724 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf