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Variation in the klotho gene is not associated with mortality risk among elderly men in MR OS Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Metabolic Bone Diseases.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
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2012 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 50, no Suppl 1, S103-S104 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Polymorphisms in the Klotho (Kl) gene, which is central for vitamin D regulation by fibroblast growth factor 23 (FGF23), have been associated with longevity, coronary disease and stroke. The CC genotype of the single nucleotide polymorphism (SNP) rs577912 in the Kl-gene is associated with decreased Kl expression, as well as increased mortality in end stage renal disease. We examined if SNP in the Kl-gene was associated with mortality in the community derived cohort of 70 to 80 year old males of MrOS Sweden (N = 3014).

High throughput genotyping of the KLOTHO SNPs was achieved by use of SequenomR MassEXTEND/Mass/ARRAY technology. 2738 subjects had a valid result for rs577912: CC 73.1% and CA + AA 26.9%. There were no differences in the serum levels of FGF23, phosphate, parathyroid hormone or renal function between genotypes CC and CA + AA. During a follow-up of a median of 4.5 years there were 337 deaths, 253 (12.6%) in the CC group and 84 (11.4%) in the CA + AA group. With log rank analysis there were no differences in mortality between the genotypes for all cause mortality (P = 0.39) or cardiovascular mortality (P = 0.60). None of the other SNPs in the Kl gene was associated with mortality in this cohort either.

Conclusion:

There is no association between the SNP rs577912 in the Kl-gene and mortality among elderly men.

Place, publisher, year, edition, pages
2012. Vol. 50, no Suppl 1, S103-S104 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-177460DOI: 10.1016/j.bone.2012.02.314ISI: 000304503500287OAI: oai:DiVA.org:uu-177460DiVA: diva2:576476
Conference
39th Annual Congress of the European-Calcified-Tissue-Society (ECTS), MAY 19-23, 2012, Stockholm, SWEDEN
Note

This article is part of a Special Issue entitled ECTS 2012

Available from: 2012-12-13 Created: 2012-07-13 Last updated: 2017-12-07Bibliographically approved

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Westerberg, Per-AntonKindmark, AndreasLinde, TorbjörnLjunggren, Östen

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