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Gamma-glutamyl transferase and c-reactive protein as alternative markers of metabolic abnormalities and their associated comorbidites: A prospective cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
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2012 (English)In: International Journal of Molecular Epidemiology and Genetics, ISSN 1948-1756, Vol. 3, no 4, 276-285 p.Article in journal (Refereed) Published
Abstract [en]

Background: Recent studies suggested that gamma-glutamyl transferase (GGT) and C-reactive protein (CRP) are good markers of metabolic abnormalities. We assessed the link between GGT, CRP and common metabolic abnormalities, as well their link to related diseases, such as cancer and cardiovascular disease (CVD). Methods: We selected 333,313 subjects with baseline measurements of triglycerides (TG), total cholesterol (TC), glucose, GGT and CRP in the Swedish AMORIS study. Baseline measurement of BMI was available for 63,900 persons and 77,944 had baseline measurements of HDL. Pearson correlation coefficients between CRP, GGT, and metabolic components (TG, HDL, BMI and TC) were calculated. To investigate the combined effect of GGT and CRP we created a score ranging from 0 to 6 and used Cox proportional hazard models to evaluate its association with CVD and cancer. Results: 21,216 individuals developed cancer and 47,939 CVD. GGT and TG had the strongest correlation (r=0.22). An increased risk of cancer was identified with elevated levels of GGT or CRP or both markers (GGT-CRP score ≥3); the greatest risk of cancer was found when GGT-CRP score = 6 (HR: 1.40 (95%CI: 1.31-1.48) and 1.60 (1.47-1.76) compared to GGT-CRP score = 0, respectively). Conclusion: While GGT and CRP have been shown to be associated with metabolic abnormalities previously, their association to the components investigated in this study was limited. Results did demonstrate that these markers were predictive of associated diseases, such as cancer.

Place, publisher, year, edition, pages
2012. Vol. 3, no 4, 276-285 p.
Keyword [en]
Cancer, Cardiovascular disease, CRP, GGT, Metabolic abnormalities
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-188129OAI: oai:DiVA.org:uu-188129DiVA: diva2:576616
Available from: 2012-12-13 Created: 2012-12-12 Last updated: 2012-12-13Bibliographically approved

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Holmberg, LarsGarmo, Hans
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