The influence of multimodal behavioral treatment on the consumption of acute migraine drugs: a randomized, controlled study
2012 (English)In: Cephalalgia, ISSN 0333-1024, E-ISSN 1468-2982, Vol. 32, no 4, 297-307 p.Article in journal (Refereed) Published
Objectives: To characterize overall drug use in migraine in conjunction with multimodal behavioral treatment (MBT). Methods: Seventy-six adults reporting at least two monthly migraine attacks underwent a randomized, controlled, 24-week MBT intervention. Migraine drugs and symptoms were registered in an Internet-based diary. Results: During 4256 days of baseline registration, 859 drug doses were taken during 655 of the 856 days with migraine headache. Triptans and analgesics constituted 56.7 and 38.3% of all doses with efficacy ratios of 0.41 and 0.20, respectively. Men displayed significantly lower drug efficacy (p = 0.001), and used triptans significantly less (p < 0.001) and analgesics significantly more (p < 0.001) than women. At the end of the MBT, total drug consumption decreased by 22% (p = 0.029), corresponding to 27% fewer days with migraine headache. Drug efficacy increased during MBT from 0.30 to 0.52 (p < 0.001), mainly explained by an increased proportion of mild attacks, which also was the attack category that displayed the largest increase in drug efficacy. Conclusions: Triptans were the most used and efficient drugs. MBT led to decreased and more efficient drug consumption. Men used triptans less frequently.
Place, publisher, year, edition, pages
2012. Vol. 32, no 4, 297-307 p.
Migraine, medication, multimodal behavioral treatment, gender, drug use, drug efficacy
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-172714DOI: 10.1177/0333102412437386ISI: 000301518200006OAI: oai:DiVA.org:uu-172714DiVA: diva2:576698