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The biological hallmarks of ileal carcinoids
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
2011 (English)In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 41, no 12, 1353-1360 p.Article, review/survey (Refereed) Published
Abstract [en]

Endocrine tumours derived from the small intestine, ileal carcinoids, produce and secrete the hormones tachykinins and serotonin, which induces the specific symptoms related to the tumour. Because of their low proliferation rate, they are often discovered at late stages when metastases have occurred. The biology that characterizes these tumours differs in many ways from what is generally recognized for other malignancies. In this overview, the current knowledge on the development and progression of ileal carcinoids is described.

Place, publisher, year, edition, pages
2011. Vol. 41, no 12, 1353-1360 p.
Keyword [en]
Carcinoid syndrome, midgut carcinoid, neuroendocrine tumour, serotonin, small intestine, tumour biology, well-differentiated endocrine carcinoma
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-188223DOI: 10.1111/j.1365-2362.2011.02537.xISI: 000297146400012PubMedID: 21605115OAI: oai:DiVA.org:uu-188223DiVA: diva2:576833
Available from: 2012-12-13 Created: 2012-12-13 Last updated: 2017-12-06Bibliographically approved

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Cunningham, Janet L.Janson, Eva T.

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