Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
1987 (English)In: Gastroenterology, ISSN 0016-5085, Vol. 93, no 3, 466-471 p.Article in journal (Refereed) Published
Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.
Place, publisher, year, edition, pages
1987. Vol. 93, no 3, 466-471 p.
IdentifiersURN: urn:nbn:se:uu:diva-188279ISI: A1987J580200004PubMedID: 3497069OAI: oai:DiVA.org:uu-188279DiVA: diva2:577191