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Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
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1987 (English)In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 93, no 3, 466-471 p.Article in journal (Refereed) Published
Abstract [en]

Gastric mucosal clearance of 51Cr-labeled red blood cells (51Cr-RBC) was measured in rats during a 30-min control period, a 30-min ischemic period (hemorrhage to 27 mmHg arterial pressure), and a 60-min reperfusion period (reinfusion of shed blood). In untreated (control) rats, a dramatic rise in the leakage of 51Cr-labeled red blood cells into the gastric lumen was observed during the reperfusion period. Treatment with neutrophil antiserum attenuated 51Cr-labeled red blood cell flux into the gastric lumen. Using the radioactive microsphere technique, neutrophil-depleted animals were shown to have higher blood flows in the ischemic period than the untreated rats. Bleeding of untreated rats to a mean arterial pressure of 40 mmHg resulted in blood flows that were not different from those in antiserum-treated rats bled to 27 mmHg and leakage of 51Cr-labeled red blood cells similar to that measured in antiserum-treated rats. The results of this study indicate that neutrophils play an important role in hemorrhagic shock-induced gastric bleeding.

Place, publisher, year, edition, pages
1987. Vol. 93, no 3, 466-471 p.
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Physiology
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URN: urn:nbn:se:uu:diva-188279ISI: A1987J580200004PubMedID: 3497069OAI: oai:DiVA.org:uu-188279DiVA: diva2:577191
Available from: 2012-12-14 Created: 2012-12-14 Last updated: 2017-12-06Bibliographically approved

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